Inverted South Trilogy: creation of theatrical texts based on perspectives of the south region of Rio Grande do Sul

This article discusses the starting point for the creation of the theatrical texts for the Inverted South Trilogy: southern Rio Grande do Sul, a Brazilian state. By observing the three plays and their respective genesis, it is possible to see how this region is used as the background of the works comprising the trilogy. The collection, written by Ingrid Duarte, Mario Celso, and Thalles Echeverry, professors graduated from the Universidade Federal de Pelotas, was launched during the COVID-19 pandemic with resources granted according to Federal Law n.degrees 14017 (Aldir Blanc Law). This trilogy highlights a change in perspective which goes beyond the capital of the state to address cities located outside the metropolitan areas, and demonstrates the importance of creating spaces for training and incentive to writing of plays, particularly to new authors.

Occurrence of adverse events and factors related to prognosis in a cohort of patients hospitalized with COVID-19 at University hospital - UNICAMP, Brazil

Background. In Brazil, 30.378.061 cases of COVID were reported and 662.866 deaths up to April 27 of 2022. Hospital infections and other hospital adverse events may increase the risk of death in patients with COVID-19. Methods. Cohort study that included 650 adult patients hospitalized with a diagnosis of SARS CoV-2 infection at Hospital HC-UNICAMP from March/20 to March/21. Results. Of the 650 patients included in the study, 139 (21.38%) died. Comparing the patients who died vs those who survived, we observed a statistically significant difference in the occurrence of thromboembolic and vascular events (23% vs 9.8%;OR 1.332;95%CI 1.12-1.59;p < 0,0001), ICU admission (84.9% vs 39.6%;OR 0.675;95%CI 0.62-0.74;p< 0.0001) and the occurrence of HI: bloodstream infections (30.2% vs 8.6%;OR 1.62;95%CI 1.31-1.99;p< 0.0001), VAP (52.5% vs 12.3%;OR 1.882;95%CI 1.57-2.26;p< 0.0001) and UTI (27.3% vs 7.2%;OR 1.672;95%CI 1.32-2.11;p< 0.0001). Gram negative bacteria were the most isolated (62.1%), especially K. pneumoniae, A. baumannii and P. aeruginosa, followed by gram positive bacteria (27%) and fungi (13.8%). When evaluating patients who had thromboembolic events, we observed a statistically significant association with male gender (15.9% vs 7.9%;p 0.003), mean initial D-Dimer values (10,418.00 ng/mL vs 3011.34 ng/ml;p 0.003);acute renal failure (19.1% vs 9.3%;p 0.001) and the occurrence of HI (24.4% vs 7.3%;p< 0.0001). The following factors associated with ICU admission were identified: diabetes mellitus (59.3% vs 40.5%;p< 0.0001);obesity (58.3% vs 41.7%;p 0.003);O2 saturation at admission < 88% (67.8% vs 32.2%);acute renal failure (78.6% vs 21.4%;p< 0.0001) and the occurrence of HI (87.8% vs 12.2%;p< 0.0001). Logistic regression analysis identified the following variables independently associated with death: age (OR 1,034;CI 1,015-1,052), ICU admission (OR 1,107;CI 1,596-5,868), use of vasoactive drugs (OR 2,93;CI 1,79-4,82), development of acute renal failure (OR 7,756;CI 4,537-13,26), and the occurrence of VAP (OR 2,205;CI 1,227-3,961) (Table 1). Conclusion. Adverse events, particularly HI, have an important impact on the evolution of patients with COVID-19, reinforcing the need for prevention and control measures to be optimized as an essential part of the care for these patients.

COVID 19 AND ACCESS TO HEALTH: A PANDEMIC REFLECTION OF INTELLECTUAL PROPERTY

Objectives: The study is structured around three different themes that reveal its objectives: the first aims to address the figure of the pandemic from a framework of solidarity;the second presents observations from a Human Rights point of view in its balance with Intellectual Property as well as the behavior of the government agenda and of the countries in their international commitment;the third part describes an approach to the legal figure of licenses as flexibility in the face of monopoly, analyzing interpretations as well as sensitivities in its application in the Mexican case, without neglecting to mention the general vision of the other participating countries of the WTO, with their disparate realities. Methodology: The method used is deductive and the bibliographic research technique. It is structured in introduction, development, conclusions and bibliography. Results: The article evidences the viability of invoking a compulsory license in the face of the COVID 19 pandemic, provided it has an adequate legislative and regulatory technique and be respectful to social paradigms. Contributions: Within a global pandemic scenario that has occurred since the arrival of the COVID-19 disease, different social and legal reflections are taking place in countries that participate in the WTO and in the multiple existing international agreements in relation to Intellectual Property law, with different interpretative dyes in terms of foreseen legal flexibilities versus current protectionist tendencies in a comparative law approach, which calls us to analyze the reality of a possible application of compulsory licenses from the patent point of view and as an ideal tool for accessing data. medicines. © 2021, Centro Universitario Curitiba - UNICURITIBA. All rights reserved.

Sociodemographic variables associated altered tolerance in friendship relations in the COVID-19 pandemic

Objective: to verify the association between sociodemographic variables and altered tolerance in friendship relationships during the COVID-19 pandemic. Method: cross-sectional study conducted in the five Brazilian macro-regions, from June to July 2020, through the application of a sociodemographic questionnaire, a semi-structured questionnaire and the Instrument for Assessing tolerance in friendship relationships. Fischer’s chi-square and exact tests were used for data analysis. Results: 88.9% considered satisfactory tolerance in relationships in the home environment, 82.8% had help from friends to overcome tensions, 73% perceived a change in relationships during quarantine. This change was higher among heterosexuals (p=0.001), residents in the Southeast and Midwest (p=0.001), with complete higher education (p=0.004), linked to private institutions (p<0.001) and who received help from friends during quarantine (p<0.001). Conclusion: sociodemographic factors and social support received from friends are associated with changes in tolerance in friendship relationships during the pandemic. © 2020 Universidade Federal da Bahia. All rights reserved.

Enhanced rapid commercial DNA extraction kit for the molecular detection of severe acute respiratory syndrome coronavirus 2: Easy adaptation to current protocols

INTRODUCTION: Herein, the authors describe a simple enhancement to a commercial rapid DNA extraction kit based on simple viral lysis for detecting COVID-19 via RT-qPCR. METHODS: After testing several different modifications, the adapted protocol with the best results in preliminary experiments was statistically evaluated in comparison with an automated robotic protocol. RESULTS: Processing and testing of 119 nasopharyngeal samples ultimately yielded near-perfect agreement with the automated protocol (kappa = 0.981 [95% confidence interval 0.943-1.000]). CONCLUSIONS: The low cost and rapidity of the enhanced protocol makes it suitable for adoption in laboratories diagnosing COVID-19, especially those with high demand for examinations.